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| Free radicals and hair loss, how this affect your hair |
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Free radicals and Hair Loss There are studies indicating that the "immunological reaction" plays a fundamental role in the development of alopecia ( aka androgenetic alopecia, baldness, common hair loss ). Somehow, dihydrotestosterone (DHT), used as a target for autoimmune attack, the follicle dht sees as a strange substance and focus agena every effort to eliminate it; The follicle begins a degenerative process mediated by the immune system wich finally, it cause the hair loss that you can read in any hair loss forum. That is really a free radical? A free radical is any molecule that contains one or more electrons desapareados.Los Free radicals are highly reactive molecules can cause cell damage including cell death. The cellular structures that can be more frequently damaged by free radicals are: -unsaturated fatty acids in cell membranes. -proteins, such as enzymes and membrane ion transporters Cancer-DNA ----------->! How are free radicals? Free radicals are produced continuously in the body: -Primarily through biochemical redox reactions (reduction-oxidation) with oxygen, which occur in normal cell metabolism. "Of phagocytes, in a controlled inflammatory reaction. "Sometimes, in response to exposure to ionizing radiation, ultraviolet rays, environmental pollution, excessive exercise, hyperoxia, cigarette hump ... Each free radical formed in the body can initiate a series of chain reactions that continues until eliminados.Los are free radicals Free radicals are removed from the body after various reactions with other free radicals (unpaired electrons conjunction and inactivated), or Most important due to the action of the antioxidant system SYSTEM IS ANTI-OXIDANT? The antioxidant system protects tissues from the effects of radical anti-oxidant system libres.El contains three main groups of antioxidants. Anti-oxidants primary: They prevent the formation of new free radicals, this was achieved by converting the existing free radicals are less damaging molecules before they can react, or prevent the formation of free radicals from other molecules, for example: Superoxide dismutase (SOD) converts hydrogen peroxide O2. "Glutathione peroxidase (GPx) converts hydrogen peroxide and lipid peroxides to harmless molecules before they form free radicals. -Binding Proteins metals (ferritin, ceruloplasmin): They limit the availability of Fe necessary to form OH radicals. Antioxidant effects: Capture-avoiding radical chain reactions eg: Vitamin E (alpha tocopherol) Vitamin C (ascorbate) Beta Carotene Uric acid Bilirubin Albumin Antioxidants tertiary: Repair the damaged biomolecules by free radicals. They include DNA repair enzymes and methionine sulfoxide reductase. What if the antioxidant system fails? Any deficiency in the system causes a loss of antioxidant protection of tissues against radical attack abnormal libres.Niveles GPx antioxidant enzymes SOD and reduced the total antioxidant status, have been implicated in various diseases: -Cancer -Cystic Fibrosis -Cardiovascular Disease -Sterility -Cataracts -Premature aging Rheumatoid-Arthritis Smoking is one of the largest generators of free radicals that have understood and can lead to serious diseases. It is thought that free radicals play an important role in the autoimmune response of the body to dihydrotestosterone (DHT) but is only a hypothesis that there is no scientific data verification. To date, the present greater promise derivatives of superoxide dismutase (SOD), which are potent antioxidants and probably act as immunomodulators. In premature alopecia in young people thought that the use of SOD's is essential since there is an important predisposing genetic background. |
